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From Image Comics:
"In the near future, the United States is ruled by bloodsucking vampire hordes. Only one man can end their reign of terror: Jesus H. Christ. A tale of war, love, religion and severed heads, the controversial Loaded Bible answers an age-old question: 'What Would Jesus Do?' Answer: He'd kick vampire ass."
As The Great Curve points out, though, it's going to be hard to top Jesus Christ Vampire Hunter.